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2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro RegularMinion Pro%i WZ5:`v22> % I  / 2 I o  # 3 p ~ U   D e !o#]emE %<Jeov~EMfjtFp|,S-AZ0=DK +^&7NQy(/S_dl 5Rk$=Valsz"'-@T_gos{    ) . > N ^ d n v ~ !! !!'!3!?!H!Q!Z!]!c!i!n!s!x!!!!!!!!!!!!!" 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@JU reww~ q hfoycdmvhvmou k)'t vNw  zbxin~{vnz )Zy}TyHpnJ -;=tM;LEjikD;N ɥ x|ud ujX^^ n~znU V'Q'J*Đ~8vw w rrc K ,dj, ,ej, "p Le w >  v/ qh eRh !Ȕ oydcmwho2 ƈ fX[  jsshjrrl ~zY$""d$QYz WiH?!%ηŷsk kool } S 9 slxLr P nYw  $ n ]i;l ymXPvq| NY. s! eC ֊ k)&s oׅ g "  1I www qm Xww X wuwO- (nE " w \i~xŠ gJN ugbktZvn __lum C\^Wbp| /b3FG3 ҬjMLy}vh#V ?o   qk &  ) Mq a, ltthc]Y`o ~|{nOf } vea t Www  qj %  6ev4 ˑ b ӑ TD==]m  csj B\^Xap| ~I2\ MI Bw ]r P  /  x }B }. vv vtndR ǩc v}yop ^%B  endstream endobj 90 0 obj <> endobj 91 0 obj <>stream /CIDInit/ProcSet findresource begin 12 dict begin begincmap /CMapName/Adobe-Identity-UCS def /CIDSystemInfo<>def /CMapType 2 def 1 begincodespacerange <00>endcodespacerange 3 beginbfchar <01><03BC> <02><2212> <03><00EF> endbfchar endcmap CMapName currentdict /CMap defineresource pop end end endstream endobj 86 0 obj <> endobj 93 0 obj <> endobj 94 0 obj <>stream %!PS-AdobeFont-1.0 11 dict begin /FontName /TeX_CM_Maths_Italic def /FontType 1 def /FontBBox {-31 -239 1041 750} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 8 dict dup begin /FullName (TeX_CM_Maths_Italic) readonly def /BaseFontName (TeX_CM_Maths_Italic) def end def /Encoding 256 array 0 1 255 {1 index exch /.notdef put} for dup 0 /C0 put dup 1 /C1 put dup 2 /C2 put dup 3 /C3 put dup 4 /C4 put dup 5 /C5 put dup 6 /C6 put dup 7 /C7 put dup 8 /C8 put dup 9 /C9 put dup 10 /C10 put dup 11 /C11 put dup 12 /C12 put dup 13 /C13 put dup 14 /C14 put dup 15 /C15 put dup 16 /C16 put dup 17 /C17 put dup 18 /C18 put dup 19 /C19 put dup 20 /C20 put dup 21 /C21 put dup 22 /C22 put dup 23 /C23 put dup 24 /C24 put dup 25 /C25 put dup 26 /C26 put dup 27 /C27 put dup 28 /C28 put dup 29 /C29 put dup 30 /C30 put dup 31 /C31 put dup 32 /space put dup 33 /exclam put dup 34 /quotedbl put dup 35 /numbersign put dup 36 /dollar put dup 37 /percent put dup 38 /ampersand put dup 39 /quoteright put dup 40 /parenleft put dup 41 /parenright put dup 42 /asterisk put dup 43 /plus put dup 44 /comma put dup 45 /hyphen put dup 46 /period put dup 47 /slash put dup 48 /zero put dup 49 /one put dup 50 /two put dup 51 /three put dup 52 /four put dup 53 /five put dup 54 /six put dup 55 /seven put dup 56 /eight put dup 57 /nine put dup 58 /colon put dup 59 /semicolon put dup 60 /less put dup 61 /equal put dup 62 /greater put dup 63 /question put dup 64 /at put dup 65 /A put dup 66 /B put dup 67 /C put dup 68 /D put dup 69 /E put dup 70 /F put dup 71 /G put dup 72 /H put dup 73 /I put dup 74 /J put dup 75 /K put dup 76 /L put dup 77 /M put dup 78 /N put dup 79 /O put dup 80 /P put dup 81 /Q put dup 82 /R put dup 83 /S put dup 84 /T put dup 85 /U put dup 86 /V put dup 87 /W put dup 88 /X put dup 89 /Y put dup 90 /Z put dup 91 /bracketleft put dup 92 /backslash put dup 93 /bracketright put dup 94 /asciicircum put dup 95 /underscore put dup 96 /quoteleft put dup 97 /a put dup 98 /b put dup 99 /c put dup 100 /d put dup 101 /e put dup 102 /f put dup 103 /g put dup 104 /h put dup 105 /i put dup 106 /j put dup 107 /k put dup 108 /l put dup 109 /m put dup 110 /n put dup 111 /o put dup 112 /p put dup 113 /q put dup 114 /r put dup 115 /s put dup 116 /t put dup 117 /u put dup 118 /v put dup 119 /w put dup 120 /x put dup 121 /y put dup 122 /z put dup 123 /braceleft put dup 124 /bar put dup 125 /braceright put dup 126 /asciitilde put dup 127 /Euro put readonly def currentdict end currentfile eexec M#1H5 J6o \&rtS(#v\0\޹V7Fe༙OYx5-cY9^%Y6 (efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@  o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}Rcx,TX|ZP ;o<[1? 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Td (specimens)Tj 4.3653 0 Td (were)Tj 2.1203 0 Td (confirmed)Tj -33.1991 -1.2983 Td (to)Tj 1.0261 0 Td (be)Tj 1.1508 0 Td (lung)Tj 2.007 0 Td (adenocarcinoma)Tj 6.8881 0 Td (by)Tj 1.1792 0 Td (pathologists.)Tj ET Q q 1 j 1 J 0 w 11.9999 0 0 11.9999 200.0125 256.0251 cm BT /F0 1 Tf 1 TL -0.0033 Tc 0 0 Td (EGFR)Tj 2.9858 0 Td (mutations)Tj 4.5071 0 Td (in)Tj 0.9827 0 Td (tumor)Tj 2.7544 0 Td (tissues)Tj 3.2976 0 Td (and)Tj 1.8662 0 Td (matched)Tj 4.0158 0 Td (plasma)Tj 3.4063 0 Td (samples)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 200.0125 239.0173 cm BT /F5 1 Tf 1 TL -0.004 Tc 0 0 Td (In)Tj 1.1055 0 Td (the)Tj 1.474 0 Td (total)Tj 2.0012 0 Td (109)Tj 1.6498 0 Td (tumor)Tj 2.7439 0 Td (tissues,)Tj 3.0444 0 Td (62)Tj 1.1678 0 Td (\(56.9%\))Tj 3.3109 0 Td (samples)Tj 3.3845 0 Td (harbored)Tj 3.8891 0 Td (EGFR)Tj 2.6533 0 Td (mutations,)Tj 4.507 0 Td (of)Tj 1.0148 0 Td (which)Tj 2.6475 0 Td (31)Tj -34.5937 -1.3039 Td (\(50.0%\))Tj 3.3108 0 Td (samples)Tj 3.3789 0 Td (carried)Tj 3.0387 0 Td (single)Tj 2.5341 0 Td (EGFR)Tj 2.6533 0 Td (E19Del,)Tj 3.3732 0 Td (23)Tj 1.1678 0 Td (\(37.1%\))Tj 3.3109 0 Td (single)Tj 2.5341 0 Td (L858R)Tj 2.8063 0 Td (mutation,)Tj 4.1442 0 Td (1\(1.6%\))Tj -32.2523 -1.2982 Td (G719X)Tj 3.016 0 Td (mutation,)Tj 4.1442 0 Td (1)Tj 0.6973 0 Td (\(1.6%\))Tj 2.8347 0 Td (exon)Tj 2.16 0 Td (20)Tj 1.1735 0 Td (insertion)Tj 3.8097 0 Td (\(E20-ins\))Tj 3.9515 0 Td (mutation)Tj 3.9175 0 Td (and)Tj 1.7291 0 Td (6)Tj 0.6973 0 Td (\(9.7%\))Tj 2.8346 0 Td (double)Tj 2.9594 0 Td (muta-)Tj -33.9248 -1.2983 Td (tions)Tj 2.1996 0 Td (\(1)Tj 1.0375 0 Td (had)Tj 1.7064 0 Td (both)Tj 2.0636 0 Td (E19Dels)Tj 3.5036 0 Td (and)Tj 1.7348 0 Td (L858R,)Tj 3.0274 0 Td (3)Tj 0.6973 0 Td (had)Tj 1.7122 0 Td (both)Tj 2.0579 0 Td (L858R)Tj 2.8063 0 Td (and)Tj 1.7291 0 Td (T790M,)Tj 3.3789 0 Td (2)Tj 0.6916 0 Td (had)Tj 1.7121 0 Td (both)Tj 2.058 0 Td (E19Dels)Tj 3.5093 0 Td (and)Tj -35.6256 -1.3039 Td (T790M\).)Tj 3.7133 0 Td (E19Del)Tj 3.1464 0 Td (was)Tj 1.7008 0 Td (the)Tj 1.4684 0 Td (most)Tj 2.2053 0 Td (common)Tj 3.8494 0 Td (EGFR)Tj 2.6532 0 Td (mutation)Tj 3.9175 0 Td (and)Tj 1.7348 0 Td (L858R)Tj 2.8063 0 Td (was)Tj 1.6951 0 Td (the)Tj 1.474 0 Td (second.)Tj 3.2315 0 Td (The)Tj 1.7858 0 Td (pro-)Tj -35.3818 -1.2983 Td (portion)Tj 3.2371 0 Td (of)Tj 1.0148 0 Td (other)Tj 2.3471 0 Td (EGFR)Tj 2.6532 0 Td (mutation)Tj 3.9231 0 Td (subtypes)Tj 3.668 0 Td (such)Tj 2.0579 0 Td (as)Tj 1.0148 0 Td (G719X)Tj 3.0161 0 Td (and)Tj 1.7291 0 Td (E20-ins)Tj 3.2712 0 Td (was)Tj 1.6951 0 Td (low.)Tj -0.007 Tc -28.4313 -1.2982 Td (In)Tj 1.1055 0 Td (the)Tj 1.4626 0 Td (matched)Tj 3.651 0 Td (plasma)Tj 3.0161 0 Td (samples,)Tj 3.5829 0 Td (the)Tj 1.457 0 Td (EGFR)Tj 2.6419 0 Td (mutations)Tj 4.2576 0 Td (positive)Tj 3.2939 0 Td (rate)Tj 1.7348 0 Td (was)Tj 1.6894 0 Td (45.9%)Tj 2.6135 0 Td (\(50/109\),)Tj -31.7024 -1.2983 Td (which)Tj 2.6362 0 Td (is)Tj 0.839 0 Td (similar)Tj 2.965 0 Td (to)Tj 1.0205 0 Td (what)Tj 2.1543 0 Td (in)Tj 1.0261 0 Td (tumor)Tj 2.7326 0 Td (tissue)Tj 2.4378 0 Td (\(P)Tj 1.1112 0 Td (=)Tj 0.7993 0 Td (0.1359\).)Tj 3.3619 0 Td (Of)Tj 1.2529 0 Td (the)Tj 1.457 0 Td (50)Tj 1.1679 0 Td (EGFR)Tj 2.6419 0 Td (mutation)Tj 3.8947 0 Td (positive)Tj 3.2939 0 Td (plasma)Tj -34.7922 -1.3039 Td (samples,)Tj 3.5829 0 Td (25)Tj 1.1622 0 Td (\(50.0%\))Tj 3.2939 0 Td (harbored)Tj 3.8607 0 Td (single)Tj 2.5172 0 Td (E19Dels,)Tj 3.7077 0 Td (21)Tj 1.1622 0 Td (\(42.0%\))Tj 3.2938 0 Td (single)Tj 2.5115 0 Td (L858R)Tj 2.7892 0 Td (mutation,)Tj 4.1216 0 Td (1)Tj 0.6916 0 Td (\(2.0%\))Tj -32.6945 -1.2983 Td (E20-ins)Tj 3.2428 0 Td (mutation)Tj 3.9004 0 Td (and)Tj 1.7178 0 Td (3)Tj 0.6973 0 Td (\(6.0%\))Tj 2.812 0 Td (double)Tj 2.9423 0 Td (mutations)Tj 4.2576 0 Td (\(2)Tj 1.0262 0 Td (E19Del)Tj 3.1294 0 Td (+)Tj 0.7993 0 Td (T790M,)Tj 3.3562 0 Td (1)Tj 0.6917 0 Td (L858R)Tj 2.7893 0 Td (+)Tj 0.7993 0 Td (T790M\),)Tj -32.1616 -1.2983 Td (suggesting)Tj 4.3709 0 Td (a)Tj 0.652 0 Td (similar)Tj 2.965 0 Td (mutation)Tj 3.8948 0 Td (profiling)Tj 3.6737 0 Td (to)Tj 1.0205 0 Td (the)Tj 1.457 0 Td (tumor)Tj 2.7325 0 Td (tissues.)Tj 3.0161 0 Td (Twelve)Tj 3.05 0 Td (patients)Tj 3.3392 0 Td (were)Tj 2.1147 0 Td (detected)Tj 3.5376 0 Td (to)Tj -35.824 -1.3039 Td (be)Tj 1.1451 0 Td (EGFR)Tj 2.6419 0 Td (mutation)Tj 3.8948 0 Td (positive)Tj 3.2938 0 Td (in)Tj 1.0262 0 Td (tumor)Tj 2.7325 0 Td (tissues)Tj 2.795 0 Td (but)Tj 1.5477 0 Td (negative)Tj 3.5093 0 Td (in)Tj 1.0318 0 Td (plasma)Tj 3.0103 0 Td (samples)Tj 3.3619 0 Td (\()Tj 0.83 0.64 0.02 0 k (S3)Tj 1.5024 0 Td (Table)Tj 0 g (\).)Tj 2.9877 0 Td (Of)Tj -34.4804 -1.2982 Td (these)Tj 2.2393 0 Td (mutations)Tj 4.2519 0 Td (in)Tj 1.0319 0 Td (tumor)Tj 2.7269 0 Td (tissues,)Tj 3.0217 0 Td (6)Tj 0.6916 0 Td (were)Tj 2.109 0 Td (E19Del,)Tj 3.3562 0 Td (3)Tj 0.6916 0 Td (L858R,)Tj 3.0104 0 Td (1)Tj 0.6973 0 Td (G719X,)Tj 3.2202 0 Td (and)Tj 1.7234 0 Td (2)Tj 0.6917 0 Td (L858R+T790M.)Tj ET Q q 0.45 0.36 0.35 0.01 k 1 j 1 J 0 w 199.9998 703.8893 m 575.9997 703.8893 l 575.9997 703.3893 l 199.9998 703.3893 l f* 340.6683 703.3893 m 340.6683 690.8893 l 340.1683 690.8893 l 340.1683 703.3893 l f* 340.1683 690.8893 m 199.9998 690.8893 l 199.9998 691.3894 l 340.1683 691.3894 l f* 474.8074 703.3893 m 474.8074 690.8893 l 474.3074 690.8893 l 474.3074 703.3893 l f* 474.3074 690.8893 m 340.6683 690.8893 l 340.6683 691.3894 l 474.3074 691.3894 l f* 575.9991 690.8893 m 474.8074 690.8893 l 474.8074 691.3894 l 575.9991 691.3894 l f* 340.6683 690.8893 m 340.6683 678.3894 l 340.1683 678.3894 l 340.1683 690.8893 l f* 340.1683 678.3894 m 199.9998 678.3894 l 199.9998 678.8894 l 340.1683 678.8894 l f* 474.8074 690.8893 m 474.8074 678.3894 l 474.3074 678.3894 l 474.3074 690.8893 l f* 474.3074 678.3894 m 340.6683 678.3894 l 340.6683 678.8894 l 474.3074 678.8894 l f* 575.9991 678.3894 m 474.8074 678.3894 l 474.8074 678.8894 l 575.9991 678.8894 l f* 340.6683 678.3894 m 340.6683 665.8894 l 340.1683 665.8894 l 340.1683 678.3894 l f* 340.1683 665.8894 m 199.9998 665.8894 l 199.9998 666.3895 l 340.1683 666.3895 l f* 474.8074 678.3894 m 474.8074 665.8894 l 474.3074 665.8894 l 474.3074 678.3894 l f* 474.3074 665.8894 m 340.6683 665.8894 l 340.6683 666.3895 l 474.3074 666.3895 l f* 575.9991 665.8894 m 474.8074 665.8894 l 474.8074 666.3895 l 575.9991 666.3895 l f* 340.6683 665.8894 m 340.6683 653.3895 l 340.1683 653.3895 l 340.1683 665.8894 l f* 340.1683 653.3895 m 199.9998 653.3895 l 199.9998 653.8895 l 340.1683 653.8895 l f* 474.8074 665.8894 m 474.8074 653.3895 l 474.3074 653.3895 l 474.3074 665.8894 l f* 474.3074 653.3895 m 340.6683 653.3895 l 340.6683 653.8895 l 474.3074 653.8895 l f* 575.9991 653.3895 m 474.8074 653.3895 l 474.8074 653.8895 l 575.9991 653.8895 l f* 340.6683 653.3895 m 340.6683 640.8896 l 340.1683 640.8896 l 340.1683 653.3895 l f* 340.1683 640.8896 m 199.9998 640.8896 l 199.9998 641.3896 l 340.1683 641.3896 l f* 474.8074 653.3895 m 474.8074 640.8896 l 474.3074 640.8896 l 474.3074 653.3895 l f* 474.3074 640.8896 m 340.6683 640.8896 l 340.6683 641.3896 l 474.3074 641.3896 l f* 575.9991 640.8896 m 474.8074 640.8896 l 474.8074 641.3896 l 575.9991 641.3896 l f* 340.6683 640.8896 m 340.6683 628.3896 l 340.1683 628.3896 l 340.1683 640.8896 l f* 340.1683 628.3896 m 199.9998 628.3896 l 199.9998 628.8897 l 340.1683 628.8897 l f* 474.8074 640.8896 m 474.8074 628.3896 l 474.3074 628.3896 l 474.3074 640.8896 l f* 474.3074 628.3896 m 340.6683 628.3896 l 340.6683 628.8897 l 474.3074 628.8897 l f* 575.9991 628.3896 m 474.8074 628.3896 l 474.8074 628.8897 l 575.9991 628.8897 l f* 340.6683 628.3896 m 340.6683 615.8897 l 340.1683 615.8897 l 340.1683 628.3896 l f* 340.1683 615.8897 m 199.9998 615.8897 l 199.9998 616.3897 l 340.1683 616.3897 l f* 474.8074 628.3896 m 474.8074 615.8897 l 474.3074 615.8897 l 474.3074 628.3896 l f* 474.3074 615.8897 m 340.6683 615.8897 l 340.6683 616.3897 l 474.3074 616.3897 l f* 575.9991 615.8897 m 474.8074 615.8897 l 474.8074 616.3897 l 575.9991 616.3897 l f* 340.6683 615.8897 m 340.6683 603.3898 l 340.1683 603.3898 l 340.1683 615.8897 l f* 340.1683 603.3898 m 199.9998 603.3898 l 199.9998 603.8898 l 340.1683 603.8898 l f* 474.8074 615.8897 m 474.8074 603.3898 l 474.3074 603.3898 l 474.3074 615.8897 l f* 474.3074 603.3898 m 340.6683 603.3898 l 340.6683 603.8898 l 474.3074 603.8898 l f* 575.9991 603.3898 m 474.8074 603.3898 l 474.8074 603.8898 l 575.9991 603.8898 l f* 340.6683 603.3898 m 340.6683 590.8898 l 340.1683 590.8898 l 340.1683 603.3898 l f* 340.1683 590.8898 m 199.9998 590.8898 l 199.9998 591.3899 l 340.1683 591.3899 l f* 474.8074 603.3898 m 474.8074 590.8898 l 474.3074 590.8898 l 474.3074 603.3898 l f* 474.3074 590.8898 m 340.6683 590.8898 l 340.6683 591.3899 l 474.3074 591.3899 l f* 575.9991 590.8898 m 474.8074 590.8898 l 474.8074 591.3899 l 575.9991 591.3899 l f* 340.6683 590.8898 m 340.6683 578.3899 l 340.1683 578.3899 l 340.1683 590.8898 l f* 340.1683 578.3899 m 199.9998 578.3899 l 199.9998 578.8899 l 340.1683 578.8899 l f* 474.8074 590.8898 m 474.8074 578.3899 l 474.3074 578.3899 l 474.3074 590.8898 l f* 474.3074 578.3899 m 340.6683 578.3899 l 340.6683 578.8899 l 474.3074 578.8899 l f* 575.9991 578.3899 m 474.8074 578.3899 l 474.8074 578.8899 l 575.9991 578.8899 l f* 340.6683 578.3899 m 340.6683 565.89 l 340.1683 565.89 l 340.1683 578.3899 l f* 340.1683 565.89 m 199.9998 565.89 l 199.9998 566.39 l 340.1683 566.39 l f* 474.8074 578.3899 m 474.8074 565.89 l 474.3074 565.89 l 474.3074 578.3899 l f* 474.3074 565.89 m 340.6683 565.89 l 340.6683 566.39 l 474.3074 566.39 l f* 575.9991 565.89 m 474.8074 565.89 l 474.8074 566.39 l 575.9991 566.39 l f* 340.6683 565.89 m 340.6683 553.39 l 340.1683 553.39 l 340.1683 565.89 l f* 340.1683 553.39 m 199.9998 553.39 l 199.9998 553.89 l 340.1683 553.89 l f* 474.8074 565.89 m 474.8074 553.39 l 474.3074 553.39 l 474.3074 565.89 l f* 474.3074 553.39 m 340.6683 553.39 l 340.6683 553.89 l 474.3074 553.89 l f* 575.9991 553.39 m 474.8074 553.39 l 474.8074 553.89 l 575.9991 553.89 l f* 340.6683 553.39 m 340.6683 540.8901 l 340.1683 540.8901 l 340.1683 553.39 l f* 340.1683 540.8901 m 199.9998 540.8901 l 199.9998 541.3901 l 340.1683 541.3901 l f* 474.8074 553.39 m 474.8074 540.8901 l 474.3074 540.8901 l 474.3074 553.39 l f* 474.3074 540.8901 m 340.6683 540.8901 l 340.6683 541.3901 l 474.3074 541.3901 l f* 575.9991 540.8901 m 474.8074 540.8901 l 474.8074 541.3901 l 575.9991 541.3901 l f* 340.6683 540.8901 m 340.6683 528.3901 l 340.1683 528.3901 l 340.1683 540.8901 l f* 340.1683 528.3901 m 199.9998 528.3901 l 199.9998 528.8902 l 340.1683 528.8902 l f* 474.8074 540.8901 m 474.8074 528.3901 l 474.3074 528.3901 l 474.3074 540.8901 l f* 474.3074 528.3901 m 340.6683 528.3901 l 340.6683 528.8902 l 474.3074 528.8902 l f* 575.9991 528.3901 m 474.8074 528.3901 l 474.8074 528.8902 l 575.9991 528.8902 l f* 340.6683 528.3901 m 340.6683 515.8902 l 340.1683 515.8902 l 340.1683 528.3901 l f* 340.1683 515.8902 m 199.9998 515.8902 l 199.9998 516.3902 l 340.1683 516.3902 l f* 474.8074 528.3901 m 474.8074 515.8902 l 474.3074 515.8902 l 474.3074 528.3901 l f* 474.3074 515.8902 m 340.6683 515.8902 l 340.6683 516.3902 l 474.3074 516.3902 l f* 575.9991 515.8902 m 474.8074 515.8902 l 474.8074 516.3902 l 575.9991 516.3902 l f* 340.6683 515.8902 m 340.6683 503.3903 l 340.1683 503.3903 l 340.1683 515.8902 l f* 340.1683 503.3903 m 199.9998 503.3903 l 199.9998 503.8903 l 340.1683 503.8903 l f* 474.8074 515.8902 m 474.8074 503.3903 l 474.3074 503.3903 l 474.3074 515.8902 l f* 474.3074 503.3903 m 340.6683 503.3903 l 340.6683 503.8903 l 474.3074 503.8903 l f* 575.9991 503.3903 m 474.8074 503.3903 l 474.8074 503.8903 l 575.9991 503.8903 l f* 340.6683 503.3903 m 340.6683 490.8903 l 340.1683 490.8903 l 340.1683 503.3903 l f* 340.1683 490.8903 m 199.9998 490.8903 l 199.9998 491.3904 l 340.1683 491.3904 l f* 474.8074 503.3903 m 474.8074 490.8903 l 474.3074 490.8903 l 474.3074 503.3903 l f* 474.3074 490.8903 m 340.6683 490.8903 l 340.6683 491.3904 l 474.3074 491.3904 l f* 575.9991 490.8903 m 474.8074 490.8903 l 474.8074 491.3904 l 575.9991 491.3904 l f* 340.6683 490.8903 m 340.6683 478.3904 l 340.1683 478.3904 l 340.1683 490.8903 l f* 340.1683 478.3904 m 199.9998 478.3904 l 199.9998 478.8904 l 340.1683 478.8904 l f* 474.8074 490.8903 m 474.8074 478.3904 l 474.3074 478.3904 l 474.3074 490.8903 l f* 474.3074 478.3904 m 340.6683 478.3904 l 340.6683 478.8904 l 474.3074 478.8904 l f* 575.9991 478.3904 m 474.8074 478.3904 l 474.8074 478.8904 l 575.9991 478.8904 l f* 340.6683 478.3904 m 340.6683 465.8905 l 340.1683 465.8905 l 340.1683 478.3904 l f* 340.1683 465.8905 m 199.9998 465.8905 l 199.9998 466.3905 l 340.1683 466.3905 l f* 474.8074 478.3904 m 474.8074 465.8905 l 474.3074 465.8905 l 474.3074 478.3904 l f* 474.3074 465.8905 m 340.6683 465.8905 l 340.6683 466.3905 l 474.3074 466.3905 l f* 575.9991 465.8905 m 474.8074 465.8905 l 474.8074 466.3905 l 575.9991 466.3905 l f* 340.6683 465.8905 m 340.6683 453.3905 l 340.1683 453.3905 l 340.1683 465.8905 l f* 340.1683 453.3905 m 199.9998 453.3905 l 199.9998 453.8906 l 340.1683 453.8906 l f* 474.8074 465.8905 m 474.8074 453.3905 l 474.3074 453.3905 l 474.3074 465.8905 l f* 474.3074 453.3905 m 340.6683 453.3905 l 340.6683 453.8906 l 474.3074 453.8906 l f* 575.9991 453.3905 m 474.8074 453.3905 l 474.8074 453.8906 l 575.9991 453.8906 l f* 340.6683 453.3905 m 340.6683 440.8906 l 340.1683 440.8906 l 340.1683 453.3905 l f* 340.1683 440.8906 m 199.9998 440.8906 l 199.9998 441.3906 l 340.1683 441.3906 l f* 474.8074 453.3905 m 474.8074 440.8906 l 474.3074 440.8906 l 474.3074 453.3905 l f* 474.3074 440.8906 m 340.6683 440.8906 l 340.6683 441.3906 l 474.3074 441.3906 l f* 575.9991 440.8906 m 474.8074 440.8906 l 474.8074 441.3906 l 575.9991 441.3906 l f* 340.6683 440.8906 m 340.6683 428.3906 l 340.1683 428.3906 l 340.1683 440.8906 l f* 340.1683 428.3906 m 199.9998 428.3906 l 199.9998 428.8907 l 340.1683 428.8907 l f* 474.8074 440.8906 m 474.8074 428.3906 l 474.3074 428.3906 l 474.3074 440.8906 l f* 474.3074 428.3906 m 340.6683 428.3906 l 340.6683 428.8907 l 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2.8233 0 Td (by)Tj 1.1735 0 Td (next)Tj 1.9445 0 Td (generation)Tj -29.9846 -1.3039 Td (sequencing)Tj 4.6828 0 Td (\(NGS\).)Tj 3.0387 0 Td (Since)Tj 2.3414 0 Td (the)Tj 1.4626 0 Td (EGFR)Tj 2.6419 0 Td (mutation)Tj 3.8948 0 Td (subtype)Tj 3.2882 0 Td (\(G719S\))Tj 3.4979 0 Td (was)Tj 1.6894 0 Td (not)Tj 1.5648 0 Td (covered)Tj 3.3278 0 Td (by)Tj 1.1792 0 Td (the)Tj 1.457 0 Td (current)Tj -34.0665 -1.2983 Td (ADx-SuperARMS)Tj 7.404 0 Td (EGFR)Tj 2.6419 0 Td (assay,)Tj 2.4718 0 Td (this)Tj 1.6611 0 Td (case)Tj 1.8538 0 Td (with)Tj 1.9842 0 Td (G719X)Tj 2.9991 0 Td (mutation)Tj 3.8948 0 Td (was)Tj 1.6951 0 Td (defined)Tj 3.2031 0 Td (as)Tj 1.0091 0 Td (a)Tj 0.652 0 Td (wild)Tj 1.9332 0 Td (type)Tj 1.8992 0 Td (in)Tj -35.3024 -1.2983 Td (both)Tj 2.0466 0 Td (plasma)Tj 3.016 0 Td (and)Tj 1.7178 0 Td (tumor)Tj 2.7326 0 Td (tissue)Tj 2.4377 0 Td (in)Tj 1.0318 0 Td (the)Tj 1.457 0 Td (following)Tj 3.9572 0 Td (comparisons)Tj 5.3007 0 Td (and)Tj 1.7235 0 Td (therefore)Tj 3.8267 0 Td (the)Tj 1.457 0 Td (total)Tj 1.9899 0 Td (inconsistent)Tj -32.6945 -1.3039 Td (cases)Tj 2.1996 0 Td (between)Tj 3.5036 0 Td (the)Tj 1.457 0 Td (paired)Tj 2.7326 0 Td (samples)Tj 3.3562 0 Td (were)Tj 2.109 0 Td (eleven)Tj 2.7155 0 Td (\()Tj 0.83 0.64 0.02 0 k (Table)Tj 2.7553 0 Td (2)Tj 0 g (\).)Tj 1.2472 0 Td (Besides,)Tj 3.3619 0 Td (as)Tj 1.0035 0 Td (for)Tj 1.3662 0 Td (the)Tj 1.457 0 Td (4)Tj 0.686 0 Td (cases)Tj 2.2054 0 Td (with)Tj 1.9785 0 Td (acquired)Tj -34.1345 -1.2983 Td (EGFR-TKI)Tj 4.6034 0 Td (resistance,)Tj 4.3256 0 Td (two)Tj 1.7008 0 Td (of)Tj 1.0091 0 Td (them)Tj 2.2734 0 Td (were)Tj 2.1146 0 Td (E19Del+T790M)Tj 6.6217 0 Td (positive)Tj 3.2882 0 Td (both)Tj 2.0523 0 Td (in)Tj 1.0261 0 Td (tumor)Tj 2.7326 0 Td (tissue)Tj 2.4378 0 Td (and)Tj 1.7234 0 Td (in)Tj -35.909 -1.2982 Td (plasma,)Tj 3.2371 0 Td (one)Tj 1.6894 0 Td (was)Tj 1.6895 0 Td (L858R+T790M)Tj 6.2815 0 Td (positive)Tj 3.2938 0 Td (in)Tj 1.0318 0 Td (tumor)Tj 2.727 0 Td (tissue)Tj 2.4377 0 Td (but)Tj 1.5477 0 Td (single)Tj 2.5115 0 Td (L858R)Tj 2.795 0 Td (positive)Tj 3.2881 0 Td (in)Tj 1.0318 0 Td (plasma,)Tj -33.5619 -1.3039 Td (and)Tj 1.7177 0 Td (one)Tj 1.6895 0 Td (was)Tj 1.6951 0 Td (single)Tj 2.5115 0 Td (L858R)Tj 2.7892 0 Td (positive)Tj 3.2939 0 Td (in)Tj 1.0318 0 Td (tumor)Tj 2.7269 0 Td (tissue)Tj 2.4378 0 Td (but)Tj 1.5477 0 Td (L858R+T790M)Tj 6.2815 0 Td (positive)Tj 3.2938 0 Td (in)Tj 1.0319 0 Td (plasma.)Tj ET Q q 1 j 1 J 0 w 11.9999 0 0 11.9999 200.0125 323.3763 cm BT /F0 1 Tf 1 TL -0.0033 Tc 0 0 Td (The)Tj 1.9275 0 Td (sensitivity)Tj 4.5024 0 Td (and)Tj 1.8615 0 Td (specificity)Tj 4.5024 0 Td (of)Tj 1.0488 0 Td (ADx-SuperARMS)Tj 7.9276 0 Td (EGFR)Tj 2.9859 0 Td (assay)Tj 2.8063 0 Td (in)Tj -27.5624 -1.1669 Td (detecting)Tj 4.2283 0 Td (plasma)Tj 3.4064 0 Td (EGFR)Tj 2.9811 0 Td (mutation)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 200.0125 292.3653 cm BT /F5 1 Tf 1 TL -0.004 Tc 0 0 Td (Firstly,)Tj 2.9706 0 Td (the)Tj 1.4684 0 Td (analytical)Tj 4.0081 0 Td (sensitivity)Tj 4.2236 0 Td (and)Tj 1.7292 0 Td (specificity)Tj 4.2122 0 Td (of)Tj 1.0148 0 Td (the)Tj 1.4684 0 Td (ADx-SuperARMS)Tj 7.4437 0 Td (assays)Tj 2.6248 0 Td (for)Tj 1.389 0 Td (EGFR)Tj -32.5528 -1.2982 Td (E19Dels,)Tj 3.7247 0 Td (L858R,)Tj 3.0217 0 Td (and)Tj 1.7234 0 Td (T790M)Tj 3.1408 0 Td (mutations)Tj 4.2746 0 Td (were)Tj 2.1146 0 Td (evaluated)Tj 3.9799 0 Td (by)Tj 1.1735 0 Td (using)Tj 2.3811 0 Td (a)Tj 0.6463 0 Td (series)Tj 2.4207 0 Td (of)Tj 1.0035 0 Td (mock)Tj 2.4605 0 Td (DNA)Tj 2.364 0 Td (samples)Tj -34.4293 -1.3039 Td (\()Tj 0.83 0.64 0.02 0 k (S1)Tj 1.508 0 Td (File)Tj 0 g (\).)Tj 2.2507 0 Td (As)Tj 1.2642 0 Td (the)Tj 1.474 0 Td (mutant)Tj 3.1465 0 Td (percentage)Tj 4.5467 0 Td (went)Tj 2.177 0 Td (from)Tj 2.2053 0 Td (5%)Tj 1.4514 0 Td (down)Tj 2.4888 0 Td (to)Tj 1.0261 0 Td (0.1%,)Tj 2.3754 0 Td (the)Tj 1.4684 0 Td (mean)Tj /F11 1 Tf 2.4491 0 Td ()Tj /F5 1 Tf (Ct)Tj 1.7688 0 Td (values)Tj 2.6702 0 Td (of)Tj 1.0148 0 Td (the)Tj -35.2854 -1.2983 Td (three)Tj 2.262 0 Td (subtypes)Tj 3.6737 0 Td (of)Tj 1.0148 0 Td (EGFR)Tj 2.6532 0 Td (mutations,)Tj 4.507 0 Td (namely)Tj 3.1465 0 Td (E19Dels,)Tj 3.7303 0 Td (L858R,)Tj 3.0331 0 Td (and)Tj 1.7291 0 Td (T790M,)Tj 3.3789 0 Td (ranged)Tj 2.9877 0 Td (from)Tj 2.2053 0 Td (6.3)Tj 1.4003 0 Td (to)Tj -35.7219 -1.2983 Td (11.6,)Tj 2.0976 0 Td (from)Tj 2.2053 0 Td (6.4)Tj 1.3947 0 Td (to)Tj 1.0261 0 Td (11.4)Tj 1.8708 0 Td (as)Tj 1.0148 0 Td (well)Tj 1.8199 0 Td (as)Tj 1.0148 0 Td (from)Tj 2.2053 0 Td (2.7)Tj 1.4003 0 Td (to)Tj 1.0261 0 Td (10.8,)Tj 2.0977 0 Td (respectively)Tj 4.8812 0 Td (\()Tj 0.83 0.64 0.02 0 k (Table)Tj 2.7836 0 Td (3)Tj 0 g (\).)Tj 1.2586 0 Td (With)Tj 2.279 0 Td (the)Tj 1.474 0 Td (thresholds)Tj 4.371 0 Td (of)Tj -36.2208 -1.3039 Td (the)Tj 1.4683 0 Td (positive)Tj 3.3165 0 Td (callings)Tj 3.2088 0 Td (recommended)Tj 6.0378 0 Td (in)Tj 1.0374 0 Td (the)Tj 1.4684 0 Td (manufacturer's)Tj 6.2645 0 Td (instruction,)Tj 4.8642 0 Td (we)Tj 1.3266 0 Td (obtained)Tj 3.7304 0 Td (true)Tj 1.8425 0 Td (posi-)Tj -34.5654 -1.2982 Td (tives)Tj 2.0239 0 Td (for)Tj 1.3833 0 Td (all)Tj 1.1508 0 Td (three)Tj 2.2621 0 Td (EGFR)Tj 2.6532 0 Td (mutations)Tj 4.2803 0 Td (subtypes)Tj 3.6736 0 Td (at)Tj 0.9525 0 Td (a)Tj 0.6519 0 Td (mutant)Tj 3.1465 0 Td (level)Tj 2.0182 0 Td (of)Tj 1.0148 0 Td (0.2%)Tj 2.1487 0 Td (or)Tj 1.0998 0 Td (more,)Tj 2.5682 0 Td (suggesting)Tj 4.405 0 Td (a)Tj ET Q q 0.45 0.36 0.35 0.01 k 1 j 1 J 0 w 199.9998 708.4721 m 575.9997 708.4721 l 575.9997 707.972 l 199.9998 707.972 l f* 317.1368 707.972 m 317.1368 682.9722 l 316.6367 682.9722 l 316.6367 707.972 l f* 316.6367 682.9722 m 199.9998 682.9722 l 199.9998 683.4722 l 316.6367 683.4722 l f* 385.5909 707.972 m 385.5909 682.9722 l 385.0909 682.9722 l 385.0909 707.972 l f* 385.0909 682.9722 m 317.1368 682.9722 l 317.1368 683.4722 l 385.0909 683.4722 l f* 506.6331 707.972 m 506.6331 695.4721 l 506.1331 695.4721 l 506.1331 707.972 l f* 506.1331 695.4721 m 385.5909 695.4721 l 385.5909 695.9721 l 506.1331 695.9721 l f* 575.9994 682.9722 m 506.6331 682.9722 l 506.6331 683.4722 l 575.9994 683.4722 l f* 445.6551 695.4721 m 445.6551 682.9722 l 445.155 682.9722 l 445.155 695.4721 l f* 445.155 682.9722 m 385.5909 682.9722 l 385.5909 683.4722 l 445.155 683.4722 l f* 506.6331 695.4721 m 506.6331 682.9722 l 506.1331 682.9722 l 506.1331 695.4721 l f* 506.1331 682.9722 m 445.6551 682.9722 l 445.6551 683.4722 l 506.1331 683.4722 l f* 317.1368 682.9722 m 317.1368 645.4723 l 316.6367 645.4723 l 316.6367 682.9722 l f* 316.6367 645.4723 m 199.9998 645.4723 l 199.9998 645.9724 l 316.6367 645.9724 l f* 385.5909 682.9722 m 385.5909 670.4722 l 385.0909 670.4722 l 385.0909 682.9722 l f* 385.0909 670.4722 m 317.1368 670.4722 l 317.1368 670.9723 l 385.0909 670.9723 l f* 445.6551 682.9722 m 445.6551 670.4722 l 445.155 670.4722 l 445.155 682.9722 l f* 445.155 670.4722 m 385.5909 670.4722 l 385.5909 670.9723 l 445.155 670.9723 l f* 506.6331 682.9722 m 506.6331 670.4722 l 506.1331 670.4722 l 506.1331 682.9722 l f* 506.1331 670.4722 m 445.6551 670.4722 l 445.6551 670.9723 l 506.1331 670.9723 l f* 575.9994 670.4722 m 506.6331 670.4722 l 506.6331 670.9723 l 575.9994 670.9723 l f* 385.5909 670.4722 m 385.5909 657.9723 l 385.0909 657.9723 l 385.0909 670.4722 l f* 385.0909 657.9723 m 317.1368 657.9723 l 317.1368 658.4723 l 385.0909 658.4723 l f* 445.6551 670.4722 m 445.6551 657.9723 l 445.155 657.9723 l 445.155 670.4722 l f* 445.155 657.9723 m 385.5909 657.9723 l 385.5909 658.4723 l 445.155 658.4723 l f* 506.6331 670.4722 m 506.6331 657.9723 l 506.1331 657.9723 l 506.1331 670.4722 l f* 506.1331 657.9723 m 445.6551 657.9723 l 445.6551 658.4723 l 506.1331 658.4723 l f* 575.9994 657.9723 m 506.6331 657.9723 l 506.6331 658.4723 l 575.9994 658.4723 l f* 385.5909 657.9723 m 385.5909 645.4723 l 385.0909 645.4723 l 385.0909 657.9723 l f* 385.0909 645.4723 m 317.1368 645.4723 l 317.1368 645.9724 l 385.0909 645.9724 l f* 445.6551 657.9723 m 445.6551 645.4723 l 445.155 645.4723 l 445.155 657.9723 l f* 445.155 645.4723 m 385.5909 645.4723 l 385.5909 645.9724 l 445.155 645.9724 l f* 506.6331 657.9723 m 506.6331 645.4723 l 506.1331 645.4723 l 506.1331 657.9723 l f* 506.1331 645.4723 m 445.6551 645.4723 l 445.6551 645.9724 l 506.1331 645.9724 l f* 575.9994 645.4723 m 506.6331 645.4723 l 506.6331 645.9724 l 575.9994 645.9724 l f* 317.1368 645.4723 m 317.1368 632.9724 l 316.6367 632.9724 l 316.6367 645.4723 l f* 316.6367 632.9724 m 199.9998 632.9724 l 199.9998 633.4724 l 316.6367 633.4724 l f* 575.9994 632.9724 m 317.1368 632.9724 l 317.1368 633.4724 l 575.9994 633.4724 l f* 317.1368 632.9724 m 317.1368 620.4725 l 316.6367 620.4725 l 316.6367 632.9724 l f* 316.6367 620.4725 m 199.9998 620.4725 l 199.9998 620.9725 l 316.6367 620.9725 l f* 575.9994 620.4725 m 317.1368 620.4725 l 317.1368 620.9725 l 575.9994 620.9725 l f* 317.1368 620.4725 m 317.1368 607.9725 l 316.6367 607.9725 l 316.6367 620.4725 l f* 316.6367 607.9725 m 199.9998 607.9725 l 199.9998 608.4726 l 316.6367 608.4726 l f* 575.9994 607.9725 m 317.1368 607.9725 l 317.1368 608.4726 l 575.9994 608.4726 l f* 317.1368 607.9725 m 317.1368 595.4726 l 316.6367 595.4726 l 316.6367 607.9725 l f* 316.6367 595.4726 m 199.9998 595.4726 l 199.9998 595.9726 l 316.6367 595.9726 l f* 575.9994 595.4726 m 317.1368 595.4726 l 317.1368 595.9726 l 575.9994 595.9726 l f* 317.1368 595.4726 m 317.1368 582.9727 l 316.6367 582.9727 l 316.6367 595.4726 l f* 316.6367 582.9727 m 199.9998 582.9727 l 199.9998 583.4727 l 316.6367 583.4727 l f* 575.9994 582.9727 m 317.1368 582.9727 l 317.1368 583.4727 l 575.9994 583.4727 l f* 575.9994 549.2225 m 199.9998 549.2225 l 199.9998 549.7226 l 575.9994 549.7226 l f* 0.83 0.64 0.02 0 k 200.0126 536.1449 m 350.7591 536.1449 l h f* 0 g 7.9999 0 0 7.9999 200.0125 713.3102 cm BT /F2 1 Tf 1 TL -0.005 Tc 0 0 Td (Table)Tj 2.7992 0 Td (2.)Tj 1.2614 0 Td (Comparis)Tj 4.5497 0 Td (on)Tj 1.4315 0 Td (of)Tj 1.1551 0 Td (EGFR)Tj 2.9764 0 Td (mutatio)Tj 3.5646 0 Td (n)Tj 0.8291 0 Td (status)Tj 3.1182 0 Td (in)Tj 1.1055 0 Td (matched)Tj 4.2732 0 Td (plasma)Tj 3.6213 0 Td (and)Tj 1.9772 0 Td (tissue)Tj 3.0685 0 Td (samples)Tj 4.1599 0 Td (\(N)Tj 1.2614 0 Td (=)Tj 0.7937 0 Td (109\).)Tj 0 Tc -14.4568 -1.8567 Td (Tumo)Tj 2.7142 0 Td (r)Tj 0.6166 0 Td (Tissue)Tj 7.7599 0 Td (Total)Tj -15.1301 -1.559 Td (Mt)Tj 7.5048 0 Td (Wt)Tj /F0 1 Tf -30.9545 -1.5662 Td (Plasma)Tj 15.0166 0 Td (Mt)Tj 8.5536 0 Td (50)Tj 7.5119 0 Td (0)Tj 7.6182 0 Td (50)Tj -23.6837 -1.559 Td (Wt)Tj 8.5536 0 Td (11)Tj 7.5119 0 Td (48)Tj 7.6182 0 Td (59)Tj -23.6837 -1.5662 Td (Total)Tj 8.5536 0 Td (61)Tj 7.5119 0 Td (48)Tj 7.6182 0 Td (109)Tj -38.7003 -1.5591 Td (Sensitivi)Tj 3.6921 0 Td (ty)Tj /F4 1 Tf [()]TJ /F0 1 Tf 22.2947 0 Td (82.0%)Tj 3.0402 0 Td (\(72.3%-91.6%)Tj 6.2929 0 Td (\))Tj -35.3199 -1.5661 Td (Specifici)Tj 3.6921 0 Td (ty)Tj /F4 1 Tf [()]TJ /F0 1 Tf 21.8836 0 Td (100%)Tj 2.7638 0 Td (\(100.0%-)Tj 4.0253 0 Td (100.0%\))Tj -32.3648 -1.5591 Td (PPV)Tj /F4 1 Tf [()]TJ /F0 1 Tf 25.1576 0 Td (100.0%)Tj 3.593 0 Td (\(100.0%-10)Tj 5.1307 0 Td 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All Rights Reserved. U.S. Patent Des. 337,604. Other patents pending. 11 dict begin /FontName /MinionPro-Bold def /FontType 1 def /FontBBox {-125 -239 1052 750} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 8 dict dup begin /FullName (MinionPro-Bold) readonly def /BaseFontName (MinionPro-Bold) def /Notice (\\050c\\051 2000, 2002 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604. Other patents pending.) readonly def end def /Encoding 256 array 0 1 255 {1 index exch /.notdef put} for dup 32 /space put dup 33 /exclam put dup 34 /quotedbl put dup 35 /numbersign put dup 36 /dollar put dup 37 /percent put dup 38 /ampersand put dup 39 /quoteright put dup 40 /parenleft put dup 41 /parenright put dup 42 /asterisk put dup 43 /plus put dup 44 /comma put dup 45 /hyphen put dup 46 /period put dup 47 /slash put dup 48 /zero put dup 49 /one put dup 50 /two put dup 51 /three put dup 52 /four put dup 53 /five put dup 54 /six put dup 55 /seven put dup 56 /eight put dup 57 /nine put dup 58 /colon put dup 59 /semicolon put dup 60 /less put dup 61 /equal put dup 62 /greater put dup 63 /question put dup 64 /at put dup 65 /A put dup 66 /B put dup 67 /C put dup 68 /D put dup 69 /E put dup 70 /F put dup 71 /G put dup 72 /H put dup 73 /I put dup 74 /J put dup 75 /K put dup 76 /L put dup 77 /M put dup 78 /N put dup 79 /O put dup 80 /P put dup 81 /Q put dup 82 /R put dup 83 /S put dup 84 /T put dup 85 /U put dup 86 /V put dup 87 /W put dup 88 /X put dup 89 /Y put dup 90 /Z put dup 91 /bracketleft put dup 92 /backslash put dup 93 /bracketright put dup 94 /asciicircum put dup 95 /underscore put dup 96 /quoteleft put dup 97 /a put dup 98 /b put dup 99 /c put dup 100 /d put dup 101 /e put dup 102 /f put dup 103 /g put dup 104 /h put dup 105 /i put dup 106 /j put dup 107 /k put dup 108 /l put dup 109 /m put dup 110 /n put dup 111 /o put dup 112 /p put dup 113 /q put dup 114 /r put dup 115 /s put dup 116 /t put dup 117 /u put dup 118 /v put dup 119 /w put dup 120 /x put dup 121 /y put dup 122 /z put dup 123 /braceleft put dup 124 /bar put dup 125 /braceright put dup 126 /asciitilde put dup 127 /Euro put dup 132 /Eth put dup 133 /eth put dup 134 /Thorn put dup 135 /thorn put dup 136 /onequarter put dup 137 /onehalf put dup 139 /plusminus put dup 161 /exclamdown put dup 162 /cent put dup 163 /sterling put dup 164 /fraction put dup 165 /yen put dup 166 /florin put dup 167 /section put dup 168 /currency put dup 169 /quotesingle put dup 170 /quotedblleft put dup 171 /guillemotleft put dup 172 /guilsinglleft put dup 173 /guilsinglright put dup 177 /endash put dup 178 /dagger put dup 179 /daggerdbl put dup 180 /periodcentered put dup 182 /paragraph put dup 183 /bullet put dup 184 /quotesinglbase put dup 185 /quotedblbase put dup 186 /quotedblright put dup 187 /guillemotright put dup 188 /ellipsis put dup 189 /perthousand put dup 191 /questiondown put dup 193 /grave put dup 194 /acute put dup 195 /circumflex put dup 196 /tilde put dup 197 /macron put dup 198 /breve put dup 199 /dotaccent put dup 200 /dieresis put dup 202 /ring put dup 203 /cedilla put dup 205 /hungarumlaut put dup 206 /ogonek put dup 207 /caron put dup 208 /emdash put dup 225 /AE put dup 227 /ordfeminine put dup 232 /Lslash put dup 233 /Oslash put dup 234 /OE put dup 235 /ordmasculine put dup 241 /ae put dup 245 /dotlessi put dup 248 /lslash put dup 249 /oslash put dup 250 /oe put dup 251 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endobj 792 0 obj <>stream %!PS-AdobeFont-1.0 %%This font is a conversion from Helvetica with the following copyright notice: %Copyright (c) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. 11 dict begin /FontName /Helvetica def /FontType 1 def /FontBBox {-156 -218 1000 770} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 8 dict dup begin /FullName (Helvetica) readonly def /BaseFontName (Helvetica) def /Notice (Copyright \(c\) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries.) readonly def end def /Encoding 256 array 0 1 255 {1 index exch /.notdef put} for dup 32 /space put dup 33 /exclam put dup 34 /quotedbl put dup 35 /numbersign put dup 36 /dollar put dup 37 /percent put dup 38 /ampersand put dup 39 /quoteright put dup 40 /parenleft put dup 41 /parenright put dup 42 /asterisk put dup 43 /plus put dup 44 /comma put dup 45 /hyphen put dup 46 /period put dup 47 /slash put dup 48 /zero put dup 49 /one put dup 50 /two put dup 51 /three put dup 52 /four put dup 53 /five put dup 54 /six put dup 55 /seven put dup 56 /eight put dup 57 /nine put dup 58 /colon put dup 59 /semicolon put dup 60 /less put dup 61 /equal put dup 62 /greater put dup 63 /question put dup 64 /at put dup 65 /A put dup 66 /B put dup 67 /C put dup 68 /D put dup 69 /E put dup 70 /F put dup 71 /G put dup 72 /H put dup 73 /I put dup 74 /J put dup 75 /K put dup 76 /L put dup 77 /M put dup 78 /N put dup 79 /O put dup 80 /P put dup 81 /Q put dup 82 /R put dup 83 /S put dup 84 /T put dup 85 /U put dup 86 /V put dup 87 /W put dup 88 /X put dup 89 /Y put dup 90 /Z put dup 91 /bracketleft put dup 92 /backslash put dup 93 /bracketright put dup 94 /asciicircum put dup 95 /underscore put dup 96 /quoteleft put dup 97 /a put dup 98 /b put dup 99 /c put dup 100 /d put dup 101 /e put dup 102 /f put dup 103 /g put dup 104 /h put dup 105 /i put dup 106 /j put dup 107 /k put dup 108 /l put dup 109 /m put dup 110 /n put dup 111 /o put dup 112 /p put dup 113 /q put dup 114 /r put dup 115 /s put dup 116 /t put dup 117 /u put dup 118 /v put dup 119 /w put dup 120 /x put dup 121 /y put dup 122 /z put dup 123 /braceleft put dup 124 /bar put dup 125 /braceright put dup 126 /asciitilde put dup 161 /exclamdown put dup 162 /cent put dup 163 /sterling put dup 164 /fraction put dup 165 /yen put dup 166 /florin put dup 167 /section put dup 168 /currency put dup 169 /quotesingle put dup 170 /quotedblleft put dup 171 /guillemotleft put dup 172 /guilsinglleft put dup 173 /guilsinglright put dup 174 /fi put dup 175 /fl put dup 177 /endash put dup 178 /dagger put dup 179 /daggerdbl put dup 180 /periodcentered put dup 182 /paragraph put dup 183 /bullet put dup 184 /quotesinglbase put dup 185 /quotedblbase put dup 186 /quotedblright put dup 187 /guillemotright put dup 188 /ellipsis put dup 189 /perthousand put dup 191 /questiondown put dup 193 /grave put dup 194 /acute put dup 195 /circumflex put dup 196 /tilde put dup 197 /macron put dup 198 /breve put dup 199 /dotaccent put dup 200 /dieresis put dup 202 /ring put dup 203 /cedilla put dup 205 /hungarumlaut put dup 206 /ogonek put dup 207 /caron put dup 208 /emdash put dup 225 /AE put dup 227 /ordfeminine put dup 232 /Lslash put dup 233 /Oslash put dup 234 /OE put dup 235 /ordmasculine put dup 241 /ae put dup 245 /dotlessi put dup 248 /lslash put dup 249 /oslash put dup 250 /oe put dup 251 /germandbls put readonly def currentdict end currentfile eexec M#1H5 J6o \&rtS(#v\0\޹V7Fe༙OYx5-cY9^%Y6 (efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@  o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)w Rfxpc @X$UČc@:p:20eַl&^ ZXs/ 1&Kk; C^AW;sdhB %0Ƚ.TALūSfW(/`k{T V6T?p*7 bBhJ2E%p (+R⪻Yt+r' 9t'#N/[MXD5s s^AAo^aj-}gCĢQұs=Y)JW3SYR}4xY~ީۘjYw}N-@Hrۢ[(/Iɒ2\# <:-fzbF,+~k Ead2^4i49X` W%ou@mVN5z4`L .%Fg!<7!/;:J듍a vHLK@u|u^?MHW <^BmZ4Ww#æs[ T^}CԢvyn^%*pTz$wK:W.z&Ύe;/ͻ|-]jT䎋4Ϲ- 9_8*8ۙ?Dw[ߦpH"@@ xJ_Oi;P2'Rк^*CVmHIx_2ρ"XI0,emB2AEvkD| ,O$ Lh3B#Vl''CImF &Zly1)~7!G ' q \m kvQ^f&KDnpH,:j ؜m t+ZzF??֍wL]BfguSEE<]*E@..$@t$6ڃ1mP|?T3VPߙˣ@Pܠ[Yٕҟf6mZR%#6P?1|}%qaBo*M*mpM3s@]c*utR 0`|pKߴE:h.YpmǍe1# !c/H+²|:.3Lҽ\)oBAVseu8+Ao'QӝmeN#/h ewǤMϓscHmVӅXN,8X$;䪓 D:lٸ'N› T ĭRB`4\TxwUgkgl#fK,{s +!v 7SP Jċoڶݞ xw EɈTh-+m^ذYa??1xҷ3kؠVlzn/0*F| qHb 빡{Y!"zy;S=Á^հɎDZ#dvVLs=mY5muQH^a !SZndHx`f-Ў\0w7ۧI lnPqlf&؇vB i%iMJNc(W$aq@(gw8p./-)WB5$?"2pP֠M\rWNVӻ9Lcs(9*&(9U;ZTD-Gd-zЯ?Ss/S}',6njԊXc5v=A]WGz 'Pӆ%fEsb6@Pj.;9k Z KN#vdJ#bDb^ LNJ W#Z3fIJf;T`lSyItf-';f hAu;V F9#D@ AJא'$]{L찕oU0-et]n/pH$ƺі*WCsr;Յv끦vAӷBTS|>VfG¿A;Y%eǪw%w}-HR' `>-'6mZ8rN􂲎Mtj\?n)HPB3/nUݳyS~yݣǿ#-Ww? 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F.͛N¶LMCƢ[*D 3́vWO.Eƾ.j=71V/*rL %޽4گ|5w63 L.aD2/9 ˫o)V m]K[}b")l \g8VqIf.1]U-#4Fst5:1m hyzi.R {2^A&bjj-eyTZoV`@NK 6^*/҅zFC旱LS|bNuӳѣQ X9ԏ 6vQDa1"Iɑ;J'i{f _v|X! 7PoS9l/ qgpRo, ,w_4t0IMYRb[{y&,c;[ 7A-iy #BG I3k"c9o=8R>N^_g\xGf?}%ccĶHm鶣!DaRmS|\?ĉ<鿓_ +ID~z:{( QpOi&qS|5RdCqzI->ꁰ d@=w!QU ;[Ruhpꯤ1R3molXrpŽM:F3VnZszJ| M24ߑ(Йbw4ߓԜRvffa;pI߼-~ҡoVDO.͊PR^kA^F|dž=.B㾕d- )-m/4,vWH@Us:};qxCAqNj!_%*Rd[lO꛴FOʁ"xvҼÄFW~ ,]aU;ltR!q;)V5{44rnvpONiQPYm uq6\} UUW MsF=>} Ne'gCaC=Ux|yAILܫ?2mE4:uA C4nǩ(Brmɵn2fA5gBk1(GZwdI[@yb:C]|-I9 Ήܱ[\ɭ E:c6@8U"`x9/G}h1Velievc nj9*՛`tVR 9 `_Q1pQ0bzfP|2Jh"w35!۪, ۗF=*suOL S Lq+\`Ʊڍ j&G1 ɪZ$Dبf`EeFFeL8*Ұ6*RE>'Ede>{ 0quPw/zݨ֋Ky|{).HB3*ɖ8v@,$J1d5VMv:Xc-}<% h^Pڏ*STNBq|@>OILH5I;ݪ$4dL9>8\<+<2g)b؉V^:F1&XEcfփa$bX ga C88:rw6*AP]Dj3 "zw#d$m'3֥_ϤvC{GOA1`_TcyO3[a:Kb^D.4sb6`"Pe[WhTE$+TCJlyaLu=u{[kjWV-VMRe WVKmW=J\䦞[D=)K?256I/b-Gˑ 29>ш7tL7ZYM8vϓ)zUV4"7g%H5f|$$:XXɠ/n DY=ع5DC8gm%^U>V.|dq[` &gN+8a D6MI/Kq:Q=Q "xNN f5'eyqF8D~5Aȇkqϡv|ͬUÓ,l7%Ǽe!7j|xC ]@%W0 ^t oveK` 35™6t'ϫqJr/69?`la3 J|e.%W=셼&a(/O>UpC 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0000000000000000000000000000000000000000000000000000000000000000 cleartomark endstream endobj 783 0 obj <> endobj 793 0 obj <> endobj 794 0 obj <>stream %!PS-AdobeFont-1.0 %%This font is a conversion from OpenSans with the following copyright notice: %Digitized data copyright \050c\051 2010-2011, Google Corporation. 11 dict begin /FontName /OpenSans def /FontType 1 def /FontBBox {-187 -239 1145 812} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 8 dict dup begin /FullName (OpenSans) readonly def /BaseFontName (OpenSans) def /Notice (Digitized data copyright \\050c\\051 2010-2011, Google Corporation.) readonly def end def /Encoding 256 array 0 1 255 {1 index exch /.notdef put} for dup 32 /space put dup 33 /exclam put dup 34 /quotedbl put dup 35 /numbersign put dup 36 /dollar put dup 37 /percent put dup 38 /ampersand put dup 39 /quoteright put dup 40 /parenleft put dup 41 /parenright put dup 42 /asterisk put dup 43 /plus put dup 44 /comma put dup 45 /hyphen put dup 46 /period put dup 47 /slash put dup 48 /zero put dup 49 /one put dup 50 /two put dup 51 /three put dup 52 /four put dup 53 /five put dup 54 /six put dup 55 /seven put dup 56 /eight put dup 57 /nine put dup 58 /colon put dup 59 /semicolon put dup 60 /less put dup 61 /equal put dup 62 /greater put dup 63 /question put dup 64 /at put dup 65 /A put dup 66 /B put dup 67 /C put dup 68 /D put dup 69 /E put dup 70 /F put dup 71 /G put dup 72 /H put dup 73 /I put dup 74 /J put dup 75 /K put dup 76 /L put dup 77 /M put dup 78 /N put dup 79 /O put dup 80 /P put dup 81 /Q put dup 82 /R put dup 83 /S put dup 84 /T put dup 85 /U put dup 86 /V put dup 87 /W put dup 88 /X put dup 89 /Y put dup 90 /Z put dup 91 /bracketleft put dup 92 /backslash put dup 93 /bracketright put dup 94 /asciicircum put dup 95 /underscore put dup 96 /quoteleft put dup 97 /a put dup 98 /b put dup 99 /c put dup 100 /d put dup 101 /e put dup 102 /f put dup 103 /g put dup 104 /h put dup 105 /i put dup 106 /j put dup 107 /k put dup 108 /l put dup 109 /m put dup 110 /n put dup 111 /o put dup 112 /p put dup 113 /q put dup 114 /r put dup 115 /s put dup 116 /t put dup 117 /u put dup 118 /v put dup 119 /w put dup 120 /x put dup 121 /y put dup 122 /z put dup 123 /braceleft put dup 124 /bar put dup 125 /braceright put dup 126 /asciitilde put dup 127 /Euro put dup 128 /ff put dup 132 /Eth put dup 133 /eth put dup 134 /Thorn put dup 135 /thorn put dup 136 /onequarter put dup 137 /onehalf put dup 139 /plusminus put dup 161 /exclamdown put dup 162 /cent put dup 163 /sterling put dup 164 /fraction put dup 165 /yen put dup 166 /florin put dup 167 /section put dup 168 /currency put dup 169 /quotesingle put dup 170 /quotedblleft put dup 171 /guillemotleft put dup 172 /guilsinglleft put dup 173 /guilsinglright put dup 177 /endash put dup 178 /dagger put dup 179 /daggerdbl put dup 180 /periodcentered put dup 182 /paragraph put dup 183 /bullet put dup 184 /quotesinglbase put dup 185 /quotedblbase put dup 186 /quotedblright put dup 187 /guillemotright put dup 188 /ellipsis put dup 189 /perthousand put dup 191 /questiondown put dup 193 /grave put dup 194 /acute put dup 195 /circumflex put dup 196 /tilde put dup 197 /macron put dup 198 /breve put dup 199 /dotaccent put dup 200 /dieresis put dup 202 /ring put dup 203 /cedilla put dup 205 /hungarumlaut put dup 206 /ogonek put dup 207 /caron put dup 208 /emdash put dup 225 /AE put dup 227 /ordfeminine put dup 232 /Lslash put dup 233 /Oslash put dup 234 /OE put dup 235 /ordmasculine put dup 241 /ae put dup 245 /dotlessi put dup 248 /lslash put dup 249 /oslash put dup 250 /oe put dup 251 /germandbls put readonly def currentdict end currentfile eexec M#1H5 J6o \&rtS(#v\0\޹V7Fe༙OYx5-cY9^%Y6 (efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@  o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)pOp@GRƪDR;fa>1\!Bak [UR-5ŏݫaτU66 7 rT/34+6v)Xs"RV ֦ u0mև3d ,ڣ.Ϳߖ8/qz6۞{$FQ{eI{n]P:tkTml EYĕRyZ1\Esk!AC5n|XWҍPqX*?|h6}N@owa:^i+v`#xJwYjdld;F.m B}ؽ7m=gvK`a)"MBJ 6ה'Ir fӍ£t-?(I7EH8JB(g`Ѳ|P.y18 D|al(Q,"]:uT}-m~t,@ {WՑfP׍W{8/h89 džo8LnQ)n^0x 7uC l <3dZl)73e˥VdBE`c|CU}kE@z `(ʭN!֖֜!h"4$IXbZ}vpyRM@HrP,Cio3<؍9yc,O7o>J.ޜt7 cJL3E^|p]NG?1Cօk;PYkf 9SfPF?p-it"@/7{?a33x%Az4T+XX/ k@LcMgx0B]]`W玐=A2j:/ g&ZY!,~%\OZy탒OSM{i݈_L09P >~Ţ?d{H߂ AB'чD #(QD{XlI6YX c, ~2|2h~- "G}@NWz \T['I Oe~8>V_cf&Aj [ /Yӝ4%H35pQhTDFO5N̐R\k+Hmǧ֫K0.b.*CP>0FW0CWͲu2[%^TkkTj)J*h  VW^g/_+%l]` OʥHU2Kʨ6]ڈ@gV1ą.'2c1e'(Ȕ.$Nk"h+KT5=S.e_ Z~ DP}8&"<$wx6eKGraV[ϥV>!w[xHٜ)upU*-ˆK~]^DFb/a .`7awAҡxtqk#q9DEq oWfqF_(D> D*rt DQa@Ej:: Ջ ?ΡH>@"1>sk2,g/U/(eEuR!HKM }:yG@YJ ɷr-M`T]&Wio8XjGzz(.ɝ{_-u9jWqs,"UKv  f7Q~*a\8Gp;AF-ƻ<1[gDAOG_\K%XO𛖹cy k}4[{_' w_}fȘ q'U9 `C jrY ¨ o*SUҵ*QϿ؉B ~!%Nofkx[$ޅAPn6:7V=gOXbP&RW x_mƇA WfFho^[f|CpT=wլ=_51])52|J*'xTִ!}u'fb&bV׿Pi &HtN=9] Aije 15jiTkHh`F92{Yh3"Z]tDxQ@*}! 8tյ+rYfigfDXKw"z*kۖ A<_s@sX|zS>}EzTLQ8QҾ( I6F1#1V ֱa͗T;#sn޼8V\04oWR_؀ !'B^fNj,D_ KrX={꯮:4l6]кOH^ߗf>x5^&DDfϖRϣ }#M5d,1S'_y(т; Z5ڟt. uR&[GJtT!D~Lz\W[%".Do7py?ay3PgМ "CEuއG  oE4 ݾQN4NUNl/%ݭ\cE={B/mK|#oFS -A p9 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A+BnXbYKKv'2r;Y TVaҲW$o@nYj;،QMQ~K9 Z(;z%t-D oYWFQqgk,fiPp37Amhb5.l§mMyw?`vAß0 z&#iYcL'l?v?5燀n& Z - p記ӏ$jB-4zQXkl+i'e,.$jX'X@;(WYMZy G-iwkzS~cm?|RǺ1`re}GE[-`{9pJxL\+C;#5΀dGiFq]a GyH/eIsYgJYd1KQjٽT3=dWKtN]BqEǕ8Άd[ĎGЛ&Lʲk܊ {V*7]h,_˂>Y.*urvFhiC[ `C" ^?諰%fX^s?QEfqH4{9nh-LR9RBgK[Y(ش  S7ID`{+_,DdG-6(ÇfBYJ}  az.6z(O_iqzP"^>ܟJaэf腜xEa"U4a`&REA1D~K]z ("iׁK:WY_4ôktu^Cs=$"5[Lamӽv*evIg+6*ЩCme| iSV 猍3Ý5Rbͼ8skv VPH˯C =bb̆8¯r}$oUdt#. ]2NaóB8MG{߁9ƳsO~'xoi? >|t,Z7Epd6FKA`qA'``eqSbqnI "~6 0>5T]so {U S-SGJ &C!ċεZ+m>Tg(fӊP`Ӎ FŇWe^;ߥ-gcSq;tT290"L*$PI~hqHr 'U˨ȇc#<5Q`RASPM7 iz vp=8Z"w@ -NV;0_b*X; kixC{-%(RŐpt`t?w57L/،$hcAP*@ﷆ1oElTL>GE89u7KJɚy ĉ`g ݞl&S͹V¤Ifs ps X/}Ip&ml"q}1 \΢ [GcQxf?_{Akq.Vm,Km&\ pJe%$Έx{z?C)`LK8~3=8Zp$I$)ZV^8,rSMې`8? pe )J(rZ6v^-&IVqŵiy6Ρݧ۩.} `='|O,|VqgC{5Ԅt P9a iJ:!3rv[&Qimsw}݄+b0 w12^-Q19 vKzxJuc|PyG|s (m |G:]FEQOL*ycv]g=a*$B_e"FuHϝ@z( dQķkf@.=ձʶok*0+ThJnN9ZbzfT*0#'R+X3~4#2rݛe9xxּbXrάeÖiSeO*BM-MYCA)\[0Դ}woټhd=JDI#F?ĝn~3 3hܝMAJFY{}8Sr6!}]>0=xE, 6SZX~xf쾭;>k^/+khH?ڑ@Goз58V~+&xˆ} iw2ϼEvޗc#ɿOR1v>[G$aqZb3"; xeY@R4#B#q0f9(]n.IsԇO3"Ce["v+ZSY޶SqBY-LxWEr*pV)m0yw' e.q.Bj$v_R=M;`} {rKⷑOUl ޮ̀"E1Uв:Z3u0suY oR=vo,W&2?&C/`w>3z)4ڼF$A>I[GF٫q`A0}La1^5i3/g[2ɵ۱!&BY.Zm:yW>MJ8BOS0#R0&2 ~8-m|,y_7/ 6߸&"ȥl@~Q=QhzΏ~bOMQnpm /&ܥ={ɌeOd@ji}!M 2 _93j3c?Em^rmulqSS //t0 o3m+P| (-Ž<ZSOʕ9{z|0Z(>otq= <*DbMg]j$,HdU̵e >*or1#$ta=յf4kIF]Mjc B:#zoǽrs0'*lu5GCء uiԖW/Z:*|Fu$2Q uJ" ~Nk&E'.v>ߒ_J0:XT]Gi…Țߏn1;\뮁Q,DDHlJH$jNcu'2(.[K-] >YV]٠G'{,HUQl!W-i6‏QwrdnY|)ԿrF =ZHq{Su=8iy>$nAʋXƼ %p59%-`h9j dĮ-1xX0>.O^kc[v ڦiǨ >8|RwSwKu+G)\&\K|Dbq0̈́|C5P2 Žb DSc^}ov$U`H%2%+x~|&FphZY:_n 豳^ߟsΫN"n<61]#4X]ʔE0%T]pWfn,sD ǰn| ;Ȣmtt3hx^Dc%(Fr3v{E%Ka.e'օ(@=:P;26M)5>Z=SWk-JNή?[iܰ C"A-oOI TO!oe ?H0^mU86=>n)fBoK N8ةܐGp[hV+}C*5Ɔ?+R ~E|qAxNV.@C*~1eZQSz=r7b=EúcQȾ%NV_U!?n<, ”荎QtICfblO=it⭆e/>㲖І8Ij v++6(ЖƯ1@xY61i V5@)mnQcTRs.ڝOJcPzvk&8 "3PK/s]`b C*5.e*^SB!0:ؗC?z3^Xƛ@_9>.ُܴ̒GW( 5wA*C=n97^G#=iJiĒ ZŲ{աgaq*{U} 79¦Ơi]y:zIaaK,y%7Lsբ?:B5/U@_}p 3F-{ߥ/͜u3Z[\Lpx|2INEgY[e\#v id81Wyl/{#9?؂yk%~v^MG:⑸QSӬG0|N_T\:=YQp_,ܐ]n 2~G5M.Nu}Ǵ^SeMpY=[fI9QքmnWmKY 61`0fEŶKa*ae/öPn -nաn=$rl|3>jMG<~p'qVD]Goq!;Vb%36c >h~Mm:yu<,*CUAfGa3-4trk%tORȸLC 3sOV)xf98jrDQ;6f!_tsc'>&L`ĕVBV/Eu㿳MR\H7p5/8(ٷѺ'åA!ju Ȅ]!w2`fg('SuXl0Y 3-Ef)ɜ1985 Ka/􁵭B7R)o%-iRjI m f6&bfͳcx cVL!;HL``]%|K'C3X+Z\Ժ=@"ٖPx7GY?P54 ޮ㾮HX#O*/}_|S:i2y^3ztb1 7z_lsdg%sX} #~~ijf}LƕB`4I:T6}. Bq j0eqθ/ɺџ?u7uer6ٮxv[ǍOql2!oX ;e+SX_wOKȖ*NcIa#3B8?:tFL>P sDK:;^`8auN4R5 Xxgo0e cw[mr¢˩$SM?ÃL-]. (̢ʪJHFʊbp58jA|Z\ϺSS ;{w>eKxe2~UC 1ojĪOG}O!}=LVM3x 6GK7%oIOtVbZUWi @G> >]r36˛ȴp ){- Om%Yy{`xs/ZGOOhoq5椡U!z% DHoT B Hђ`YgUוM| G";ق/ =* 'wB\Y[3ǟE> v4 kfw.<$nKbn[k'#3 W0[c[O3d1#%BJyEuN뀜~# @&s 8Tmڷ* ~: wHTHPo p|de)pV'ܔuip :%o"F%8Lw,#@:$Dȩ: v r^-ɋ#$/8=ݷoZO4ghl\umF@K+1ݨ}lS#zL>.C kfGaϨ?D5=Z_˂ Um4-U0)IYVIP0覡%@/N;+;MFeYLXDAm3p!3O`d;XrDW4OQ hnkVeVڜ uSeCQj1"Za!j4W0.&p_sEZ>܆DvF?^L+R_6|?+s{ pt+k]pei辒@9=CJ GúI,Fpl{?Ew4[iqE.Rc9!o_s(ܪ!y,?M5=DKb𽷙ߌ B7/Q, ֆ(\3x`g1%!惕GL.5`<81 ~ Cm3l25r[A5bN蚀&4J%6em/3eL {.;d֋ FB'zx 4~v%j&n5;_ye%`gjNXZU8'+E#ч#-|qࠡ5}3iq+V/A Y:)[J|r$Fhe_wgGg8KdjA67npA'wF'j7!7Y%a&ĴFcȌY\hϴ9ҝX@`Pk n}4(` MA6v^IvFKe=xpK&7y'OŒf#6,3I/KK=n.ρ<;f[3 {al4Ч,r0 ;\i`>cQ'2t& YhxדLc4O?U ?Etn.]|5;Ӈ=qL:ޤqsAu GgUg>M2Cb2X GD|%r`Ȁ6Lnڄ}kCBӧX񷕔tK裭p %P@vSжO? 6T>=e0ǟR[.gU ;%i@+ҏ:W-a]~3JrlFfF<I<rWJvt$%*ڂX-X*>,lnFӖ*[S'3k  2IY!jz +0eÒ6lnU{<c3Ř 3YH#:eݚ_TIWFlO=Rw+BW2.wr}.581a lz/,gz}P+jW.sn4|' pۓZW/>SK-*yn IM-0g {_1-.{f'K&aG\tMSLP>6ܐ)JWy: O$L x"Mc-қ*Iː*RpDX.zx{Y m# ` em+`/v+_KAs^5)'^u_tLe爃rf }ր"tVݙ.Fw4fkuv !z1fi5wZnm'5w)*skZx2j8^ g\S2B o*a$sҞAgAxi2XSp]~֖"_SJh]T <ÉăN6ՊA?7>/4?y: WP7ہ,=A?>0ucDȲ_D@QVVP dt(MW:>"l l tҾ6[7X<_Aj5EKhP~|ڞ0®50Pf#ݫP=mP}RPOpYWA/LtPQgy8-{:FsȆ<]P\ oyB5*+@A_GFiG^2tXlX}D_R ?FB0NӅAFf: F]>*$3d,D$Wm8MC#뒧m"_^LBIq;;?/3:zxlUG5lnt*(Q Ivj(^ 4ᡝ4ͤ1 +"4xyDo!k LVwa}UsG!$>ϔ;hWXnL<8S+6L'K-4jΦȲ0YZy#y0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 0000000000000000000000000000000000000000000000000000000000000000 cleartomark endstream endobj 6 0 obj <> endobj 795 0 obj <> endobj 796 0 obj <>stream %!PS-AdobeFont-1.0 %%This font is a conversion from Helvetica-Bold with the following copyright notice: %Copyright (c) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. 11 dict begin /FontName /Helvetica-Bold def /FontType 1 def /FontBBox {-166 -218 1000 770} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 8 dict dup begin /FullName (Helvetica-Bold) readonly def /BaseFontName (Helvetica-Bold) def /Notice (Copyright \(c\) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries.) readonly def end def /Encoding 256 array 0 1 255 {1 index exch /.notdef put} for dup 32 /space put dup 33 /exclam put dup 34 /quotedbl put dup 35 /numbersign put dup 36 /dollar put dup 37 /percent put dup 38 /ampersand put dup 39 /quoteright put dup 40 /parenleft put dup 41 /parenright put dup 42 /asterisk put dup 43 /plus put dup 44 /comma put dup 45 /hyphen put dup 46 /period put dup 47 /slash put dup 48 /zero put dup 49 /one put dup 50 /two put dup 51 /three put dup 52 /four put dup 53 /five put dup 54 /six put dup 55 /seven put dup 56 /eight put dup 57 /nine put dup 58 /colon put dup 59 /semicolon put dup 60 /less put dup 61 /equal put dup 62 /greater put dup 63 /question put dup 64 /at put dup 65 /A put dup 66 /B put dup 67 /C put dup 68 /D put dup 69 /E put dup 70 /F put dup 71 /G put dup 72 /H put dup 73 /I put dup 74 /J put dup 75 /K put dup 76 /L put dup 77 /M put dup 78 /N put dup 79 /O put dup 80 /P put dup 81 /Q put dup 82 /R put dup 83 /S put dup 84 /T put dup 85 /U put dup 86 /V put dup 87 /W put dup 88 /X put dup 89 /Y put dup 90 /Z put dup 91 /bracketleft put dup 92 /backslash put dup 93 /bracketright put dup 94 /asciicircum put dup 95 /underscore put dup 96 /quoteleft put dup 97 /a put dup 98 /b put dup 99 /c put dup 100 /d put dup 101 /e put dup 102 /f put dup 103 /g put dup 104 /h put dup 105 /i put dup 106 /j put dup 107 /k put dup 108 /l put dup 109 /m put dup 110 /n put dup 111 /o put dup 112 /p put dup 113 /q put dup 114 /r put dup 115 /s put dup 116 /t put dup 117 /u put dup 118 /v put dup 119 /w put dup 120 /x put dup 121 /y put dup 122 /z put dup 123 /braceleft put dup 124 /bar put dup 125 /braceright put dup 126 /asciitilde put dup 161 /exclamdown put dup 162 /cent put dup 163 /sterling put dup 164 /fraction put dup 165 /yen put dup 166 /florin put dup 167 /section put dup 168 /currency put dup 169 /quotesingle put dup 170 /quotedblleft put dup 171 /guillemotleft put dup 172 /guilsinglleft put dup 173 /guilsinglright put dup 174 /fi put dup 175 /fl put dup 177 /endash put dup 178 /dagger put dup 179 /daggerdbl put dup 180 /periodcentered put dup 182 /paragraph put dup 183 /bullet put dup 184 /quotesinglbase put dup 185 /quotedblbase put dup 186 /quotedblright put dup 187 /guillemotright put dup 188 /ellipsis put dup 189 /perthousand put dup 191 /questiondown put dup 193 /grave put dup 194 /acute put dup 195 /circumflex put dup 196 /tilde put dup 197 /macron put dup 198 /breve put dup 199 /dotaccent put dup 200 /dieresis put dup 202 /ring put dup 203 /cedilla put dup 205 /hungarumlaut put dup 206 /ogonek put dup 207 /caron put dup 208 /emdash put dup 225 /AE put dup 227 /ordfeminine put dup 232 /Lslash put dup 233 /Oslash put dup 234 /OE put dup 235 /ordmasculine put dup 241 /ae put dup 245 /dotlessi put dup 248 /lslash put dup 249 /oslash put dup 250 /oe put dup 251 /germandbls put readonly def currentdict end currentfile eexec M#1H5 J6o \&rtS(#v\0\޹V7Fe༙OYx5-cY9^%Y6 (efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@  o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)w Rfxpc @X$UČc@:p:20eַl&^ ZXs/ 1# PGh&ɹ!R0gAZ "2 w^DVMܽ/x}KA©rhE=V~xYaI샌0 DNP)/LxN> kvc߹vutSs G'wId.t!B^nL:]u隣 \F"8\xS@v'*bt a̓;yº9;i[ֈt(Oqn`MHwT I *faQa2۳77"1d PxwT<a~f-~%r\簂ܔ?$v" PO~zD52H^!ݒ/ ʮ/t]n+?o\;VUQf3)"5/fOh-ܥ sdqG$h6Ԍę'ˏi>- zu?(wRh+8 l11 U\ Rtq ^T=.&?( !3-GԂ_K>%0O8 ~-A ІB;cyt^Bd/P55\ʽ$j8)v2 CbT!1<I gq^%öR]"vŐ@Ngc~= E)= ZgyGVG!kefkV><28d;VeZˇI:6 jC9}VYc\ؖ%$APvvv~-],y 5}(-Ś#ũ5gNg~_xY4cz=fg@'QI(~ݗ8Vj)@hEPs~p l!^po+(p(}m)B̘Wtu 'BX5;rC-%m?̫eb~{NSC"7Z#yՋ ?[`r+p#8)b~c۬67g\(g4Ek{T;Ҁ*Xی"9dZ72uygGzz1XkUE~3z4TPfNT<Vc|i2午};yDj|p ֊t^|4E!~JƾbI ̮!&GRE>YMvԸűG J?|5Za߃8p6#hF?qVs4!}Б ǯ4{D`ψa"C $^kWf Fȧ!ΰ;V. mo.'bDˠU'z3M\gDgFZ[9z$>We+gEt:;᭿ /m× לDzeX+OAfIYϕ(+PlOECV}d ?nXV32qñ$1Ѧ' cLW{ӫk_d꧇,\I>1_!F Hj'p6%a4])u~2)NbnLoaE2[R=^:  MŘVx(]h7(ϊh龝KI:t4{[ծ1꟥isA^ʊFe|@pCu:K ]ixy% C3+yI28hvf=eYE|]$VYeS:xjx\FDMn5k:KjX؁hׯ>հL!/|;*)y}@Ɣ'%;o> =zhX)!+a|)Hdg6'* j{Zxl5#AaB~1Yܨl NhFRXPq""#whN v`%郼VzG/øӓ3! 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